A possible method is developed for computing the asymptotic sampling variance-covariance matrix of joint maximum likelihood estimates in item response theory when both item parameters and abilities are unknown. For a set of artificial data, results are compared with empirical values and with the variance-covariance matrices found by the usual formulas for the case where the abilities are known, or where the item parameters are known. The results are consistent with the conjecture that the new method is asymptotically correct except for errors due to grouping. (Author/PN). (46pp.)